Endocrine Abstracts

Case history: A 51-year old female presented to emergency with occipital headache for 5 days on a background of recurrent headaches for over a year. She had been diagnosed with Hashimoto’s disease at the age of 30 and given levothyroxine, which she discontinued 5 years ago due to aversion to take medications. She had noticed cold intolerance and low energy. At presentation her body mass index was 25.26 kg/m2 and the physical exam was unremarkable; specifically,...

Background: Granulomatous mastitis (GM) is a rare inflammatory condition of the breast typically affecting women during postpartum period. GM can mimic inflammatory breast cancer and only be reliably distinguished through histopathology. While there is no generally accepted treatment for GM, therapeutic options include - antibiotics, wide surgical excision, and corticosteroids.Clinical Case: A 54-year-old female presented to her family physician with wit...

The optimum approach to long-term follow-up of well differentiated thyroid cancer (DTC) remains unclear. We assessed the outcome of DTC patients followed in primary care (PrC) from Edmonton, AB with tertiary care (TrC) settings from Halifax, NS and London, ON. Patients who met the following criteria were identified: a) Initial diagnosis between January 1, 2006 to December 31, 2011, b) primary tumourA total of 317 patients, (PrC=93 and TrC=2...

The optimum approach to long-term follow-up of well differentiated thyroid cancer (DTC) remains unclear. We assessed the outcome of DTC patients followed in primary care (PrC) from Edmonton, AB with tertiary care (TrC) settings from Halifax, NS and London, ON. Patients who met the following criteria were identified: a) Initial diagnosis between January 1, 2006 to December 31, 2011, b) primary tumourA total of 317 patients, (PrC=93 and TrC=2...

Introduction: The hypothalamic kiss1/kisspeptin system is pivotal in controlling fertility. However, kiss1 transcripts were also quantified in rat fat, where expression was regulated by oestradiol (Brown et al. 2008) and by dihydrotestosterone (DHT; Brown et al. 2009). In human fat, microarray analysis revealed abnormal, multiple gene expression in obese PCOS patients (Corton et al. 2007). In the present experiments we used a rat model (Manne...

Fat-derived adipokine genes that modulate metabolic and inflammatory responses, such as resistin (rstn) and fasting-induced adipose factor (fiaf), are also expressed in mouse brain and pituitary gland. We, and others, reported that central fiaf and rstn mRNA levels were increased following a brain injury-induced inflammatory response, and central injection of resistin reduced food intake and increased hepatic glucose production. Since LPS-induced en...

Introduction: Secondary hormonal deficiencies (SHD) are frequently observed in patients with pituitary adenomas. We previously reported that pituitary tumour clinical subtypes were associated with specific patterns of SHD, and nonfunctioning adenomas (NFAs) were more likely to present with multiple SHD. We extended our work to examine if the immunohistochemical staining patterns of NFAs impacted SHD.Methods: All clinically NFAs surgically removed between...

A 68 year old gentleman referred to endocrinology clinic with a few years history of erectile dysfunction (ED), which manifested as reduced libido and partial erections. Investigations revealed primary hypogonadism with a low morning serum Testosterone of 4.8 (Ref: 7.9-31 nmol/l), raised FSH at 47 (Ref:1.5-12.4 iu/l) LH at 36.8 (Ref: 1.7-8.6iu/l) and normal thyroid function tests (TFTs). The patient declined testosterone replacement therapy following a discussion of pros and c...

Secondary hormonal deficiency (SHD) in sellar masses (SM) is thought to be partly due to compression of the portal vessels by the enlarging tumour restricting the blood supply to the normal pituitary tissue. However, to date no study has looked at the patterns of SHD in various types of SM and assessed if SHD is related solely to the size of SM or is associated with the underlying pathology. We assessed 914 patients with SM enrolled in our comprehensive pituitary registry sinc...

Patients with sellar masses (SM) undergoing transsphenoidal surgery (TSS) have a significant risk of transient or permanent endocrine dysfunction; therefore, in-hospital endocrinology consultation (IHEC) is recommended for these patients. However, routine assessment of all TSS patients by a specialized team is not feasible outside select centers. We developed an IHEC guide for TSS patients in December 2015 to identify those patients who would require perioperative IHEC. We con...